NSC 21402

NSC 21402 - Names and Identifiers

Name	5-Amino-1,3,4-thiadiazole-2-thiol
Synonyms	AMTD NSC 21402 5-Amino-2-thiol-1,3,4-thiadiazole 5-Amino-1,3,4-thiadiazole-2-thiol 1,3,4-Thiadiazole-2-thiol, 5-amino- 2-Amino-5-mercapto-1,3,4-thiadiazole 5-Amino-2-mercapto-1,3,4-thiadiazole 5-Amino-3H-[1,3,4]thiadiazole-2-thione 5-amino-1,3,4-thiadiazole-2(3H)-thione 1,3,4-Thiadiazole-2(3H)-thione, 5-amino- ACETYLAMINE(2-)-5-MERCAPTO-1,3,4-THIADAZOLE delta2-1,3,4-Thiadiazoline-2-thiol, 5-imino-
CAS	2349-67-9
EINECS	219-078-4
InChI	InChI=1/C2H3N3S2/c3-1-4-5-2(6)7-1/h(H2,3,4)(H,5,6)
InChIKey	GDGIVSREGUOIJZ-UHFFFAOYSA-N

NSC 21402 - Physico-chemical Properties

Molecular Formula	C2H3N3S2
Molar Mass	133.2
Density	1.503 (estimate)
Melting Point	235°C (dec.)(lit.)
Boling Point	242.3±23.0 °C(Predicted)
Flash Point	100.3°C
Water Solubility	insoluble
Solubility	2g/l
Vapor Presure	0.0342mmHg at 25°C
Appearance	Powder
Color	White or pale yellow to cream
BRN	81728
pKa	7.80±0.20(Predicted)
PH	3.9 (2g/l, H2O, 20℃)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.5800 (estimate)
MDL	MFCD00003108
Physical and Chemical Properties	2-amino -5-mercapto -1,3, 4-thiadiazole neat was a white crystalline solid, m. P. 235 ℃ (decomposition), soluble in hot water and pyridine, dimethyl formamide and other organic solvents, slightly soluble in methanol, acetone.
Use	Used as pharmaceutical, pesticide intermediates

NSC 21402 - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3
RTECS	XI4550000
FLUKA BRAND F CODES	9-13-23
TSCA	Yes
HS Code	29349990
Hazard Note	Irritant

NSC 21402 - Nature

Open Data Verified Data

crystallization, melting point 233~234 C (decomposition).

Last Update：2024-01-02 23:10:35

NSC 21402 - Preparation Method

Open Data Verified Data

obtained by cyclization of bisthiourea. The above-mentioned cyclization reaction is advantageously carried out in 13% to 1 s% hydrochloric acid. The quality of bisthiourea has influence on the quality of cyclization products.

Last Update：2022-01-01 10:57:42

NSC 21402 - Application

Open Data Verified Data

The pharmaceutical industry for the synthesis of acetazolamide diuretics. Also used to determine the density of metals.

Last Update：2025-08-19 16:24:40

NSC 21402 - Safety

Open Data Verified Data

LD50 250mg/kg (mouse oral). Irritating.

Last Update：2022-01-01 10:57:42

NSC 21402 - Reference Information

NIST chemical information	Information provided by: webbook.nist.gov (external link)
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
Uses	2-amino-5-mercapto-1, 3,4-thiadiazole is an intermediate of the fungicide leaf cumazole. Pesticides and pharmaceutical intermediates. Used as an intermediate in medicine and pesticide
Production method	Dithiourea is obtained by condensation and rearrangement of hydrazine sulfate and ammonium thiocyanate, and then by cyclization reaction. The technological process is as follows:(1) condensation and rearrangement ammonium thiocyanate and hydrazine sulfate are added to water, heated to 75 ℃, kept for 2.5h, and refluxed for 2h at 100 ℃. Add 45% sulfuric acid, continue to reflux for 1h, cool to 40 ℃, discharge, continue to cool to below 25 ℃, adjust to pH3-4 with sodium hydroxide solution, filter, and wash the filter cake with ice water until pH4-5 to obtain crude dithiourea. Add water and activated carbon to the crude product, decolorize at 90 ℃ for 1h, filter, and cool and crystallize the filtrate. Filtration, the filtrate is used as reaction water. The filter cake is dried to obtain a fine product of dithiourea. 60% yield. (2) Cyclization Mix water (or dithiourea refined mother liquor) and hydrochloric acid evenly, add 0.07 parts (about 1/15 of the total) dithiourea at 60 ℃. Add calcium phosphite (or sodium phosphite) at 80°C, and add the rest of dithiourea at 85°C. Backflow for 4h. Cool to 20 ℃, filter, wash the filter cake with ice water until pH4-5, and dry to obtain 2-amino-5-mercapto-1, 3,4-thiadiazole. the preparation method is to add a small amount of hydrochloric acid and a small amount of catalyst in the reaction kettle, then add an appropriate amount of solvent, then add dithiourea under stirring, heat and rise to 105 ℃ for reflux, finish the reaction, stir and cool, filter, wash, suck and filter until dry, and dry to obtain the finished product.
category	toxic substances
toxicity classification	highly toxic
acute toxicity	abdominal cavity-mouse LD50: 250 mg/kg
flammability hazard characteristics	combustible; combustion produces toxic nitrogen oxides and sulfur oxide smoke
storage and transportation characteristics	warehouse ventilation and low temperature drying
fire extinguishing agent	dry powder, foam, sand, carbon dioxide, mist water

Last Update：2024-04-09 20:44:15

Shanghai Macklin Biochemical Co., Ltd

Featured ProductsSpot supply

Product Name: 5-Amino-1,3,4-thiadiazole-2-thiol Visit Supplier Webpage Request for quotation
CAS: 2349-67-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

Wuhan Boye Science And Technology Development Co., Ltd.

Featured Products

Product Name: 5-Amino-1,3,4-thiadiazole-2-thiol Request for quotation
CAS: 2349-67-9
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380

Jiangsu Pules Biotechnology Co.,Ltd.

Product Name: 5-Amino-1,3,4-thiadiazole-2-thiol Request for quotation
CAS: 2349-67-9
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830

JIANGSU BSECHEM CHEMICAL TECHNOLOGY CO., LTD.

Spot supply

Product Name: 5-Amino-1,3,4-thiadiazole-2-thiol Request for quotation
CAS: 2349-67-9
Tel: +86-17505207175
Email: 3787852685@qq.com
Mobile: +86-17505207175
QQ: 3787852685

Wechat: chemical6666

Nantong Reform Petro-Chemical CO., LTD.

Spot supply

Product Name: 5-Amino-1,3,4-thiadiazole-2-thiol Request for quotation
CAS: 2349-67-9
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865

Send QQ message
Wechat: chemical6666

Guangzhou Yuanda New Material Co.,Ltd

Multiple SpecificationsSpot supply

Product Name: 2-Amino-5-methio-1,3,4-thiadiazole；5-Amino-1,3,4-thiadiazole-2-thiol Request for quotation
CAS: 2349-67-9
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589

Shanghai Amole Biotechnology Co., Ltd.

Spot supply

Product Name: 5-Amino-1,3,4-thiadiazole-2-thiol Request for quotation
CAS: 2349-67-9
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365

Wechat: 18916960931

SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.

Spot supply

Product Name: 5-Amino-1,3,4-thiadiazole-2-thiol Visit Supplier Webpage Request for quotation
CAS: 2349-67-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922

Wechat: 18621343501
WhatsApp: +86-18621343501

MedChemExpress (MCE)

Multiple SpecificationsSpot supply

Product Name: 2-Amino-5-mercapto-1,3,4-thiadiazole Visit Supplier Webpage Request for quotation
CAS: 2349-67-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898

SKYRUN INDUSTRIAL CO.,LTD

Multiple SpecificationsSpot supply

Product Name: 2-Amino-5-Mercapto-134-Thiad Visit Supplier Webpage Request for quotation
CAS: 2349-67-9
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185

Send QQ message
Wechat: chinaskyrun

Shanghai Macklin Biochemical Co., Ltd

Featured ProductsSpot supply

Product Name: 5-Amino-1,3,4-thiadiazole-2-thiol Visit Supplier Webpage Request for quotation
CAS: 2349-67-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

Wuhan Boye Science And Technology Development Co., Ltd.

NSC 21402

5-Amino-1,3,4-thiadiazole-2-thiol

CAS: 2349-67-9

Molecular Formula: C2H3N3S2

NSC 21402 - Names and Identifiers

NSC 21402 - Physico-chemical Properties

NSC 21402 - Risk and Safety

NSC 21402 - Nature

Open Data Verified Data

NSC 21402 - Preparation Method

Open Data Verified Data

NSC 21402 - Application

Open Data Verified Data

NSC 21402 - Safety

Open Data Verified Data

NSC 21402 - Reference Information

Supplier List

NSC 21402 Request for Quotation

5-Amino-1,3,4-thiadiazole-2-thiol

CAS: 2349-67-9

Molecular Formula: C2H3N3S2

NSC 21402 - Names and Identifiers

NSC 21402 - Physico-chemical Properties

NSC 21402 - Risk and Safety

NSC 21402 - Nature

Open Data Verified Data

NSC 21402 - Preparation Method

Open Data Verified Data

NSC 21402 - Application

Open Data Verified Data

NSC 21402 - Safety

Open Data Verified Data

NSC 21402 - Reference Information

Supplier List

NSC 21402